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News Physiol Sci 17: 185-190, 2002; doi:10.1152/nips.01396.2002
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 5, 185-190, October 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

It Takes "Heart" to Win: What Makes the Heart Powerful?

Kerry S. McDonald and Todd J. Herron

Department of Physiology, University of Missouri, Columbia, Missouri 65212
Current address for T. J. Herron: Centre for Cardiovascular Biology and Medicine, King’s College London, The Rayne Institute, St. Thomas Hospital, London SE1 7EH, UK.

The pumping action of the heart varies considerably on a beat-to-beat basis and is ultimately determined by the extent of ventricular myocyte shortening during systole. The use of isolated myocardial preparations has provided new insights about the subcellular factors that modulate power output of the ventricles.




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