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1 Department of Physiology, Freie Universität Berlin, D-14195 Berlin;
2 German Heart Center Berlin, D-13353 Berlin, Germany; and
3 Department of Physiology, University of Arizona, Tucson, Arizona 85724-5051
The development and maintenance of the vascular system requires not only the formation of new vessels (vasculogenesis, angiogenesis) but also the continuous adjustment of vessel and network structures in response to functional needs. This "angioadaptation" depends on the interplay of vascular responses to growth factors, to the metabolic status of the tissue, and to hemodynamic forces exerted by the flowing blood.
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