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News Physiol Sci 17: 202-206, 2002; doi:10.1152/nips.01386.2002
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 5, 202-206, October 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Cholinergic Control of Heart Rate by Nitric Oxide is Site Specific

Neil Herring, Edward J. F. Danson and David J. Paterson

University Laboratory of Physiology, Oxford University, Oxford OX1 3PT, UK
Parasympathetic control of heart rate involves the exocytotic release of acetylcholine and muscarinic receptor regulation of pacemaking currents. Endogenous nitric oxide can potentially regulate all of these processes; however, recent work suggests that the main functional role of nitric oxide lies in the modulation of acetylcholine release.




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