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News Physiol Sci 17: 207-212, 2002; doi:10.1152/nips.01390.2002
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 5, 207-212, October 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Agrin in the Developing CNS: New Roles for a Synapse Organizer

Stephan Kröger and Jörn E. Schröder

Institute for Physiological Chemistry and Pathobiochemistry, University of Mainz, D-55099 Mainz, Germany
The heparan sulfate proteoglycan agrin is responsible for the formation, maintenance, and regeneration of the neuromuscular junction. In the central nervous system, agrin is widely expressed and concentrated at interneuronal synapses, but its function during synaptogenesis remains controversial. Instead, evidence for additional functions of agrin during axonal growth, establishment of the blood-brain barrier, and Alzheimer’s disease is accumulating.




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