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News Physiol Sci 17: 213-218, 2002; doi:10.1152/nips.01389.2002
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 5, 213-218, October 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Molecular Motors: Force and Movement Generated by Single Myosin II Molecules

Caspar Rüegg1, Claudia Veigel2, Justin E. Molloy2, Stephan Schmitz2, John C. Sparrow2 and Rainer H. A. Fink1

1 Department of Physiology and Pathophysiology, University of Heidelberg, INF 326, D-69126 Heidelberg, Germany; and
2 Department of Biology, University of York, York YO10 5YW, UK
Muscle myosin II is an ATP-driven, actin-based molecular motor. Recent developments in optical tweezers technology have made it possible to study movement and force production on the single-molecule level and to find out how different myosin isoforms may have adapted to their specific physiological roles.




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