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Fusion Pore in Live Cells

Bhanu P. Jena

Departments of Physiology and Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201
Earlier electrophysiological measurements on live secretory cells suggested the presence of fusion pores at the plasma membrane, where secretory vesicles fuse to release vesicular contents. Recent studies using atomic force microscopy demonstrate for the first time the presence of the fusion pore and reveal its morphology and dynamics at near-nanometer resolution and in real time.

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