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News Physiol Sci 17: 227-230, 2002; doi:10.1152/nips.01400.2002
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 6, 227-230, December 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Cerebrospinal Fluid Transport: a Lymphatic Perspective

M. Johnston and C. Papaiconomou

Neuroscience Research, Department of Laboratory Medicine and Pathobiology, Sunnybrook and Women’s College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
The textbook view that projections of the arachnoid membrane into the cranial venous sinuses represent the primary cerebrospinal fluid (CSF) absorption sites seems incompatible with many clinical and experimental observations. On balance, there is more quantitative evidence suggesting a function for extracranial lymphatic vessels than exists to support a role for arachnoid villi and granulations in CSF transport.




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