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News Physiol Sci 17: 231-234, 2002; doi:10.1152/nips.01402.2002
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 6, 231-234, December 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Transport of Xenobiotics Across the Blood-Brain Barrier

Bruno Hagenbuch, Bo Gao and Peter. J. Meier

Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH-8091 Zurich, Switzerland
Distinct transport proteins regulate the movement of waste products and xenobiotics across the blood-brain barrier (BBB). Members of the drug transporter families MDR, MRP, and OATP have been identified in the BBB, and a detailed characterization of the involved proteins is now required to target drugs more efficiently to the brain.




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