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News Physiol Sci 17: 246-250, 2002; doi:10.1152/nips.01393.2002
1548-9213/02 $5.00
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News in Physiological Sciences, Vol. 17, No. 6, 246-250, December 2002
© 2002 Int. Union Physiol. Sci./Am. Physiol. Soc.

Spatial Heterogeneity in the Heart: Recent Insights and Open Questions

Ulrich K. M. Decking

Institut für Herz- und Kreislaufphysiologie, Heinrich-Heine-Universität Düsseldorf, 40001 Düsseldorf, Germany; and Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1061
Within the left ventricular myocardium and despite its rather homogeneous structure, local myocardial perfusion varies substantially. Areas of low and high local flow differ with regard to substrate uptake, energy turnover, and demand. This spatial heterogeneity is related to distinct differences in local protein expression, forming the basis of a novel homeostatic mechanism.




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