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News Physiol Sci 18: 18-22, 2003; doi:10.1152/nips.01407.2002
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 1, 18-22, February 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Small G Proteins as Novel Therapeutic Targets in Cardiovascular Medicine

Christine Barandier, Xiu-Fen Ming and Zhihong Yang

Vascular Biology, Department of Medicine, Division of Physiology, University of Fribourg, CH-1700 Fribourg, Switzerland
Small G proteins are implicated in regulation of endothelial function, smooth muscle cell contraction, proliferation, and migration, as well as cardiomyocyte hypertrophy. Targeting small G proteins and their downstream signaling could constitute promising therapeutic approaches in cardiovascular disorders such as atherosclerosis, restenosis, hypertension, vasospasm, and cardiac hypertrophy.




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