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News Physiol Sci 18: 29-33, 2003; doi:10.1152/nips.01408.2002
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 1, 29-33, February 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Ubiquitin-Dependent Proteolysis in Neurons

Lars Klimaschewski

Institute of Anatomy and Histology, Deptartment of Neuroanatomy, University of Innsbruck, A-6010 Innsbruck, Austria
Various studies identified the ubiquitin-proteasome system as the prime suspect in causing neurodegenerative diseases. The present review summarizes our current knowledge about the expression, regulation, and functions of this major protein degradation pathway in the brain, with particular reference to the pathogenesis of associated neurological diseases.




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