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Dysfunction of Wild-Type Huntingtin in Huntington disease

Elena Cattaneo

Department of Pharmacological Sciences and Center for Excellence in Neurodegenerative Diseases, University of Milano, 20133 Milano, Italy
Huntingtin is the protein involved in Huntington disease (HD), an inherited neurodegenerative disease. Research activities have focused on the abnormal functions of mutant huntingtin. However, recent results indicate that wild-type huntingtin has important activities in brain neurons, suggesting that loss of these activities may play a role in HD.

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