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CFTR and Bicarbonate Secretion to Epithelial Cells

Martin J. Hug¹, Tsutomu Tamada² and Robert J. Bridges²

¹ Institute of Physiology, University of Münster, D-48149 Münster, Germany; and
² Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
Defective HCO₃^– and fluid secretion are hallmarks of the pathophysiology of the pancreas of cystic fibrosis patients. Recently, impaired HCO₃^– secretion has been shown in most tissues known to express the cystic fibrosis transmembrane conductance regulator (CFTR). New results suggest that CFTR plays an important role in the transcellular secretion of HCO₃^–.

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