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"The Force Be with You": ATP in Gut Mechanosensory Transduction

Helen J. Cooke¹, Jacqueline Wunderlich² and Fievos L. Christofi²

¹ Departments of Neuroscience and
² Anesthesiology, The Ohio State University, Columbus, Ohio 43210
Nucleotides such as ATP and UTP are everywhere. They play a key role in transducing mechanosensory signals via P2Y receptors in the large intestine or colon, leading to secretion of the sensory mediator 5-HT, and act as autocrine, paracrine, or neurocrine mediators in neural reflexes regulating chloride secretion.

Jacqueline Wunderlich is a visiting medical scientist from Germany.

Support for some of the studies described in this review was provided by National Institutes of Health Grants R01-DK-44179, DK-37240, DK-57016, National Center for Research Resources Grant 1S10-RR-11434, DK-44179-07S1 Fellowship, and a Samuel J. Roessler Scholarship to Jorge Guzman.

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