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News Physiol Sci 18: 60-64, 2003; doi:10.1152/nips.01424.2002
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 2, 60-64, April 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Annexin 1: An Endogenous Anti-Inflammatory Protein

Mauro Perretti and Felicity N. E. Gavins

The William Harvey Research Institute, London EC1M 6BQ, United Kingdom
A hallmark of inflammation is the mobilization of blood-borne leukocytes across microvessels to kill and remove the invading pathogen. For its damaging potential, leukocyte movement is finely regulated, and endogenous pathways exist to ensure the time dependency of this process. Annexin 1 and its receptor(s) are one example of these pathways.

F. N. E. Gavins is recipient of a Ph.D. studentship of the British Heart Foundation UK (BHF), and M. Perretti is a Senior Fellow of the Arthritis Research Campaign UK (ARC). Work in the authors’ laboratory is funded by ARC, BHF, and The Wellcome Trust UK.




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