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News Physiol Sci 18: 65-70, 2003; doi:10.1152/nips.01417.2002
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 2, 65-70, April 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Angiogenesis and Vascular Remodeling by Intussusception: From Form to Function

Haymo Kurz1, Peter H. Burri2 and Valentin G. Djonov2

1 Institute of Anatomy II, University of Freiburg, D-79104 Freiburg, Germany; and
2 Institute of Anatomy, University of Bern, CH-3012 Bern, Switzerland
Address for reprint requests and other correspondence: V. G. Djonov, Institute of Anatomy, Buehlstrasse 26, University of Berne, CH-3012 Berne, Switzerland (E-mail djonov{at}ana.unibe.ch).

During most instances of angiogenesis, not only are the capillaries or terminal vessels generated and modified, but the supplying vascular system is subjected to remodeling as well. Intussusception, i.e., transluminal pillar formation, is one essential mechanism for growth, arborization, bifurcation remodeling, and pruning. Complex and efficient vascular beds can thus be generated by local interactions between vascular cells and hemodynamic conditions.




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