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News Physiol Sci 18: 71-76, 2003; doi:10.1152/nips.01418.2002
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 2, 71-76, April 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Self Glycosphingolipids: New Antigens Recognized by Autoreactive T Lymphocytes

Gennaro De Libero and Lucia Mori

Experimental Immunology, Department of Research, University Hospital, Basel, CH-4031 Basel, Switzerland
T cells may recognize glycolipids and lipids of bacterial and self origin associated with the CD1 antigen-presenting molecules. Understanding the mechanisms governing CD1-self glycolipid interaction will provide information on the molecular rules of glycolipid presentation and suggest new approaches to immunotherapy.




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