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Arteriovenous Pairing: a Determinant of Capillary Exchange

Norman R. Harris

Department of Bioengineering, Pennsylvania State University, University Park, Pennsylvania 16802
Venuloarteriolar signaling helps mediate microvascular function and dysfunction. Mediators produced at venular sites of inflammation appear to constrict arterioles and increase capillary permeability. In contrast, venules beneficially dilate arterioles to enhance capillary flow according to metabolic demand. These mechanisms are altered with cardiovascular risk factors, contributing to microvascular complications.

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