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1 Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital/Harvard Medical School, Charlestown, Massachusetts 02129; and
2 University Hospital Basel, CH-4031 Basel, Switzerland
Erythrocytes bind immune complexes (ICs) composed of antibodies binding their respective antigen (e.g., bacteria, parasites, viruses, or autoantigen) plus complement proteins via complement receptors [immune adherence (IA)]. In vivo studies have shown that erythrocytes act as an inert shuttle, targeting ICs to fixed macrophages in liver and spleen. Here we outline established and emerging implications of IA in health and disease.
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