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News Physiol Sci 18: 115-118, 2003; doi:10.1152/nips.01429.2002
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 3, 115-118, June 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Vesicle-Mediated Restoration of a Plasmalemmal Barrier in Severed Axons

Harvey M. Fishman1 and George D. Bittner2

1 Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77555-0641; and
2 Neurobiology Section, School of Biological Sciences, The University of Texas, Austin, Texas 78712

Ca2+-induced endocytotic vesicles undergo protein-mediated interactions to restore a selectively permeable barrier and propagated action potentials in severed invertebrate giant axons. Similar barrier-restoration phenomena observed in cultured mammalian cells with transected neurites suggest that cellular/molecular mechanisms that repair plasmalemmal damage are phylogenetically conserved.




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