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News Physiol Sci 18: 130-136, 2003; doi:10.1152/nips.01414.2002
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 3, 130-136, June 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Chemotropic Molecules: Guides for Axonal Pathfinding and Cell Migration During CNS Development

Fernando de Castro

1 Neurobiología-Investigación, Hospital Ramón y Cajal, Madrid-28034; and
2 Instituto de Neurociencias de Castilla y León-INCYL, Universidad de Salamanca, Salamanca-37007, Spain
Different molecules (netrins, semaphorins, slits) with chemotropic functions and their receptors (neogenin, DCC, neuropilins, plexins, robos) have been identified that guide axons during development of the nervous system to establish the complex pattern of connections among a large number of neurons. These molecules have been recently identified to play a role in cell migration of the central nervous system during development.




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