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Nonredundant Gap Junction Functions

Thomas W. White

Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794
The need for molecular heterogeneity of gap junction channel proteins in vivo has been enigmatic. Recently, functional replacement of one channel gene with another in mice and flies has revealed that cellular health depends not simply on gap junction communication but also requires the correct type of intercellular channel subunit.

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