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News Physiol Sci 18: 137-142, 2003; doi:10.1152/nips.01415.2002
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 4, 137-142, August 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Is Survival Possible Without Arachidonate Metabolites in the Brain During Systemic Infection?

Ji Zhang and Serge Rivest

Laboratory of Molecular Endocrinology, Centre de Recherche de l’Université Laval and Department of Anatomy and Physiology, Laval University, Québec City, Québec, Canada G1V 4G2
The central nervous system mediates a coordinated set of biological responses during systemic immune stimuli. These responses are essential for the organism to eliminate invading pathogens and restore health. Coincidentally, centrally produced prostaglandins play a determinant role in activating the neuronal circuits involved in the control of autonomic functions.




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