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News Physiol Sci 18: 143-146, 2003; doi:10.1152/nips.01435.2002
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 4, 143-146, August 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Epithelial Cell Polarity From the Outside Looking In

W. James Nelson

Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, California 94305-5435
Epithelial cell polarity may be regulated by protein sorting in the Golgi and delivery to different membrane domains, a view from the inside looking out. But from the outside looking in, cell adhesion may be required first to establish sites for delivery, retention, and separation of membrane proteins, and delivery of presorted proteins from the Golgi subsequently reinforces and maintains different membrane domains.




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