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Cell Adhesion Molecules: Key Players in Memory Consolidation?

Hans Welzl¹ and Oliver Stork²

¹ Division of Neuroanatomy and Behavior, Institute of Anatomy, University of Zurich, CH-8057 Zurich, Switzerland; and
² Institute of Physiology, University of Magdeburg, School of Medicine, 39016 Magdeburg, Germany
Experimental evidence implies that L1 and neural cell adhesion molecule (NCAM) are involved in long-term memory formation. Changes in their expression and glycosylation appear to modify the synaptic strength underlying memory consolidation. Interference with L1 and NCAM function in a variety of learning tasks in different species severely attenuates memory consolidation, indicating their involvement in an evolutionary conserved mechanism of neural plasticity.

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