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News Physiol Sci 18: 158-163, 2003; doi:10.1152/nips.01440.2003
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 4, 158-163, August 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Apical Entry Channels in Calcium-Transporting Epithelia

Ji-Bin Peng1,2, Edward M. Brown3 and Matthias A. Hediger1

1 Membrane Biology Program and Renal and
2 Division of Nephrology, University of Birmingham, Birmingham, Alabama 35294
3 Endocrine-Hypertension Divisions, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115; and

The identification of the apical calcium channels CaT1 and ECaC revealed the key molecular mechanisms underlying apical calcium entry in calcium-transporting epithelia. These channels are regulated directly or indirectly by vitamin D and dietary calcium and undergo feedback control by intracellular calcium, suggesting their rate-limiting roles in transcellular calcium transport.




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