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1 Membrane Biology Program and Renal and
2 Division of Nephrology, University of Birmingham, Birmingham, Alabama 35294
3 Endocrine-Hypertension Divisions, Department of Medicine, Brigham and Womens Hospital and Harvard Medical School, Boston, Massachusetts 02115; and
The identification of the apical calcium channels CaT1 and ECaC revealed the key molecular mechanisms underlying apical calcium entry in calcium-transporting epithelia. These channels are regulated directly or indirectly by vitamin D and dietary calcium and undergo feedback control by intracellular calcium, suggesting their rate-limiting roles in transcellular calcium transport.
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