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News Physiol Sci 18: 164-168, 2003; doi:10.1152/nips.01441.2003
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 4, 164-168, August 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Found: Na+ and K+ Binding Sites of the Sodium Pump

R. F. Rakowski1 and S. Sagar2

1 Department of Biological Sciences, Ohio University, Athens, Ohio 45701; and
2 Department of Physiology and Biophysics, Finch University of Health Sciences, North Chicago, Illinois 60064
Homology modeling and valence mapping have been used to predict the location and structure of Na+ and K+ binding sites in the Na+-K+-ATPase on the basis of the known atomic resolution structure of SERCA. Additional sites are predicted that may be associated with intracellular access and extracellular egress pathways for Na+. The model predictions are in excellent agreement with previous structure-function and electrical studies.




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