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Riding the Tides: K⁺ Concentration and Volume Regulation by Muscle Na⁺-K⁺-2Cl^- Cotransport Activity

Aidar R. Gosmanov¹, Michael I. Lindinger² and Donald B. Thomason¹

¹ Department of Physiology, The University of Tennessee Health Science Center, Memphis, Tennessee 38163;
² Department of Human Biology and Nutritional Sciences, The University of Guelph, Guelph, Ontario N1G 2W1, Canada
Until recently, the existence of a Na⁺-K⁺-2Cl^- cotransporter (NKCC) in skeletal muscle was unclear. Recent evidence shows that the NKCC is strongly expressed and provides both K⁺ and water transport functions in resting and contracting skeletal muscle. The contribution of NKCC activity to K⁺ and volume regulation in skeletal muscle has potential consequences for muscle contractility and metabolism.

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