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News Physiol Sci 18: 201-204, 2003; doi:10.1152/nips.01448.2003
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 5, 201-204, October 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Cellular Redox: A Modulator of Intestinal Epithelial Cell Proliferation

Tak Yee Aw

Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130
Mucosal proliferation, together with differentiation and apoptosis, are a continuous homeostatic process in the intestinal epithelium. The glutathione/glutathione disulfide redox status plays a key role in intestinal growth control wherein a reduced redox potential maintains a proliferative state. An oxidative shift in this potential elicits growth arrest and cell transition to a differentiated or apoptotic phenotype.




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