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News Physiol Sci 18: 210-214, 2003; doi:10.1152/nips.01447.2003
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 5, 210-214, October 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Long-Term Adaptation Mechanisms in Extremity Veins Supporting Orthostatic Tolerance

Emil Monos1, Miklós Lóránt1, Gabriella Dörnyei1, Viktor Bérczi2 and György Nádasy1

1 Institute of Human Physiology and Experimental Research and
2 Department of Cardiovascular Surgery, Semmelweis University Budapest, 1082 Budapest, Hungary
Several long-term antigravity defense mechanisms are activated in the lower extremity veins and microvessels when an organism is exposed to chronic orthostatic load. These mechanisms involve acute pressure-induced myogenic response, counterregulatory K+ channels, functional and structural remodeling of sympathetic innervation, and vascular network properties.

This work was supported by the Hungarian grants OTKA T-042670/2003, OTKA C-194, ETT-149/2000, and TP 163/2003.




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