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News Physiol Sci 18: 215-221, 2003; doi:10.1152/nips.01453.2003
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 6, 215-221, December 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Matching the Heart to Heat-Induced Circulatory Load: Heat-Acclimatory Responses

Michal Horowitz

Division of Physiology, Hadassah School of Dental Medicine, The Hebrew University, Jerusalem 91120, Israel
Heat acclimation enhances cardiac efficiency by increasing stroke volume and decreasing heart rate. These adaptations involve biochemical changes in the contractile apparatus, switched on by altered expression of genes coding contractile and calcium-regulatory proteins and partially mediated by persistent low thyroxine. Heat acclimation also produces cross-tolerance to oxygen deprivation, thus reinforcing cardiac adaptation to oxygen demand/supply mismatching via energy-sparing pathways.




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