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Faculty of Kinesiology and Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 2N4, Canada
A common mechanism affecting Ca2+ sensitivity in skeletal muscle is the proximity of myosin heads with actin filaments, a function of myofilament lattice spacing and myosin head mobility with respect to the myosin filament. This is an important mechanism of pCa2+50 modulation by length, pH, regulatory light-chain phosphorylation, and temperature.
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