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News Physiol Sci 18: 242-246, 2003; doi:10.1152/nips.01460.2003
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 6, 242-246, December 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Ghrelin: A Novel Player in the Gut-Brain Regulation of Growth Hormone and Energy Balance

David H. St-Pierre1, Lixin Wang2 and Yvette Taché2

1 Faculty of Medicine, Department of Nutrition, Université de Montréal, Montréal, Québec H3C 3J7, Canada; and
2 Department of Medicine, Digestive Diseases Research Center, University of California, Los Angeles, California 90073
Ghrelin is a newly discovered peptide hormone produced by the stomach that displays potent growth hormone-releasing activity and a stimulatory effect on food intake and digestive function while reducing energy expenditure. The isolation of ghrelin has led to new insights into how this gastric hormone links the endocrine control of nutritional homeostasis with growth hormone secretion and gastrointestinal motility through gut-brain interactions.




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