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News Physiol Sci 18: 252-256, 2003; doi:10.1152/nips.01458.2003
1548-9213/03 $5.00
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News in Physiological Sciences, Vol. 18, No. 6, 252-256, December 2003
© 2003 Int. Union Physiol. Sci./Am. Physiol. Soc.

Mitochondrial Regulation of Intracellular Ca2+ Signaling: More Than Just Simple Ca2+ Buffers

Anant B. Parekh

Department of Physiology, University of Oxford, Oxford OX1 3PT, UK
Mitochondrial Ca2+ uptake shapes the profile of intracellular Ca2+ signals, both spatially and temporally. In addition, such uptake controls the gating of Ca2+ release and store-operated Ca2+ entry channels, partitions cells into subcellular Ca2+ hotspots, and can result in the release of diffusible signals into the cytosol that subsequently regulate protein function.




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