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Hypothalamic and Midbrain Circuitry That Distinguishes Between Escapable and Inescapable Pain

Bridget M. Lumb

Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
Characteristics of emotional, behavioral, and physiological responses to pain are determined to a large extent by the behavioral significance of the pain, in particular to the degree to which the pain can be escaped. This review presents evidence that these different patterns of response depend on the activation of distinct pathways within the brain.

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