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Calcium and TRP Channels in Pulmonary Vascular Smooth Muscle Cell Proliferation

Judd W. Landsberg and Jason X.-J. Yuan

Department of Medicine, School of Medicine, University of California, San Diego, California 92103
Ca²⁺ is a major trigger for pulmonary vasoconstriction and a stimulus for pulmonary vascular smooth muscle cell proliferation. The transient receptor potential cation channels participate in regulating intracellular Ca²⁺ and thus vascular contractility and cell proliferation. Upregulation of genes encoding these channels is involved in the development of pulmonary hypertension.

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