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News Physiol Sci 19: 51-54, 2004; doi:10.1152/nips.01463.2003
1548-9213/04 $5.00
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News in Physiological Sciences, Vol. 19, No. 2, 51-54, April 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

Unorthodox Sites and Modes of Aldosterone Action

Hans Oberleithner

Nanolab, Institute of Physiology II, University of Münster, 48149 Münster, Germany
Aldosterone controls electrolyte balance by acting on the renal epithelium. However, there is strong evidence that vascular endothelium is another target for mineralocorticoids. Endothelial cells gain sensitivity to diuretics when exposed to aldosterone. Atomic force microscopy detects such phenomena. It is speculated that endothelium and kidney join forces in the regulation of body fluids.




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