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News Physiol Sci 19: 75-79, 2004; doi:10.1152/nips.01503.2003
1548-9213/04 $5.00
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News in Physiological Sciences, Vol. 19, No. 2, 75-79, April 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

A Nonconventional Look at Ionic Fluxes in the Skin: Lessons From Genetically Modified Mice

Marjorie Guitard, Celine Leyvraz and Edith Hummler

Départment de Pharmacologie et de Toxicologie, Université de Lausanne, CH-1005 Lausanne, Switzerland
The mammalian, highly amiloride-sensitive epithelial sodium channel (ENaC) is member of the degenerin/ENaC superfamily of ion channels known to be implicated in sodium homeostasis, mechanosensation, and mechanoperception. A novel role for ENaC implicated in differentiation processes in skin reshapes our current view of this ancient transmembrane channel protein.




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