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Electrophysiological Insights into the Mechanism of Ion-Coupled Cotransporters

Antonio Peres, Stefano Giovannardi, Elena Bossi and Riccardo Fesce

Laboratory of Cellular and Molecular Physiology, Department of Structural and Functional Biology, and Center for Neurosciences, University of Insubria, 21100 Varese, Italy
Most ion-coupled cotransporters display, in the absence of organic substrate, transient currents resembling the gating currents of voltage-dependent ion channels. Detailed comparison of these currents in different ionic and temperature conditions with the corresponding steady-state currents when translocation of the substrate occurs reveals new insights into the mechanisms of the process.

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