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News Physiol Sci 19: 105-109, 2004; doi:10.1152/nips.01512.2003
1548-9213/04 $5.00
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News in Physiological Sciences, Vol. 19, No. 3, 105-109, June 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

Use of Recombinant Congenic Strains in Mapping Disease-Modifying Genes

Jana Müllerová1,2 and Pavel Hozák1,2

1 Department of Cell Ultrastructure and Molecular Biology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 20 Prague; and
2 Department of Cellular and Molecular Biology, Third Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic
Previous research studies have established much information about single-gene diseases. However, other genes also influencing the outcome of a disease and genes involved in complex disease remain largely unknown. Here we report on recombinant congenic strains of mice, a powerful tool for genetic dissection of a complex trait.






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