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News Physiol Sci 19: 138-147, 2004; doi:10.1152/nips.01518.2004
1548-9213/04 $5.00
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News in Physiological Sciences, Vol. 19, No. 3, 138-147, June 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

The Sarcoplasmic Reticulum, Ca2+ Trapping, and Wave Mechanisms in Smooth Muscle

John G. McCarron, Karen N. Bradley, Debbi MacMillan, Susan Chalmers and Thomas C. Muir

Institute of Biomedical and Life Sciences, Neuroscience and Biomedical Systems, University of Glasgow, Glasgow G12 8QQ, UK
The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering the cell to limit the rise in cytoplasmic Ca2+ concentration without SR pump involvement. When "leaky" the SR facilitates Ca2+ entry to the cytoplasm. SR Ca2+ release via inositol 1,4,5-trisphosphate receptors (IP3Rs) propagates as calcium waves; IP3Rs alone account for wave propagation.




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