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News Physiol Sci 19: 148-153, 2004; doi:10.1152/nips.01520.2004
1548-9213/04 $5.00
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News in Physiological Sciences, Vol. 19, No. 3, 148-153, June 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

Connexins Pave the Way for Vascular Communication

Cor de Wit

Institut für Physiologie, Universität Lübeck, 23538 Lübeck, Germany
Coordinated behavior within arterioles is necessary for large resistance changes to occur and is reflected as a conduction of dilations/constrictions along arterioles. These responses arise from locally initiated hyper- or depolarizations that propagate via transmembrane channels formed by connexins (gap junctions). Mounting evidence indicates that gap-junctional communication contributes to the control of vascular tone.




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