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Activity-Dependent Synaptic Competition at Mammalian Neuromuscular Junctions

Mario Buffelli, Giuseppe Busetto, Carlo Bidoia, Morgana Favero and Alberto Cangiano

Dipartimento di Scienze Neurologiche e della Visione, Sezione di Fisiologia, Universita’ di Verona, 37134 Verona, Italy
Synapse elimination is a widespread developmental process in the peripheral and central nervous system that brings about refinement of neural connections through epigenetic mechanisms. Here we describe recent advances concerning the role of the pattern of motoneuronal firing, synchronous or asynchronous, in neuromuscular synapse elimination.

This article has been cited by other articles:

				E. Lorenzetto, L. Caselli, G. Feng, W. Yuan, J. M. Nerbonne, J. R. Sanes, and M. Buffelli Genetic perturbation of postsynaptic activity regulates synapse elimination in developing cerebellum PNAS, September 22, 2009; 106(38): 16475 - 16480. [Abstract] [Full Text] [PDF]