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Dipartimento di Scienze Neurologiche e della Visione, Sezione di Fisiologia, Universita di Verona, 37134 Verona, Italy
Synapse elimination is a widespread developmental process in the peripheral and central nervous system that brings about refinement of neural connections through epigenetic mechanisms. Here we describe recent advances concerning the role of the pattern of motoneuronal firing, synchronous or asynchronous, in neuromuscular synapse elimination.
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