| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
First Medical Department, Hanusch Hospital, A-1140 Vienna, Austria
Rat muscle studies suggest competition between free fatty acids (FFA) and glucose for oxidation, resulting in glucose-6-phosphate accumulation. However, FFA decrease glucose-6-phosphate in human skeletal muscle, indicating direct inhibition of glucose transport/phosphorylation. This mechanism could redirect glucose from muscle to brain during fasting and explain the insulin resistance associated with high-lipid diets and obesity.
This article has been cited by other articles:
|
|
 |
|
  J. Yang, X. Kong, M. E. S. Martins-Santos, G. Aleman, E. Chaco, G. E. Liu, S.-Y. Wu, D. Samols, P. Hakimi, C.-M. Chiang, et al. Activation of SIRT1 by Resveratrol Represses Transcription of the Gene for the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) by Deacetylating Hepatic Nuclear Factor 4{alpha} J. Biol. Chem., October 2, 2009; 284(40): 27042 - 27053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Surwit, J. D. Lane, D. S. Millington, H. Zhang, M. N. Feinglos, S. Minda, R. Merwin, C. M. Kuhn, R. C. Boston, and A. Georgiades Hostility and Minimal Model of Glucose Kinetics in African American Women Psychosom Med, July 1, 2009; 71(6): 646 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fernandez-Veledo, I. Nieto-Vazquez, J. de Castro, M. P. Ramos, S. Bruderlein, P. Moller, and M. Lorenzo Hyperinsulinemia Induces Insulin Resistance on Glucose and Lipid Metabolism in a Human Adipocytic Cell Line: Paracrine Interaction with Myocytes J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2866 - 2876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Szocs, B. Brunmair, K. Stadlbauer, P. Nowotny, L. Bauer, A. Luger, and C. Furnsinn Age-Dependent Development of Metabolic Derangement and Effects of Intervention with Pioglitazone in Zucker Diabetic Fatty Rats J. Pharmacol. Exp. Ther., July 1, 2008; 326(1): 323 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. MacDonald, M. C. Petrie, N. M. Hawkins, J. R. Petrie, M. Fisher, R. McKelvie, D. Aguilar, H. Krum, and J. J.V. McMurray Diabetes, left ventricular systolic dysfunction, and chronic heart failure Eur. Heart J., May 2, 2008; 29(10): 1224 - 1240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Bikopoulos, A. da Silva Pimenta, S. C Lee, J. R Lakey, S. D Der, C. B Chan, R. B. Ceddia, M. B Wheeler, and M. Rozakis-Adcock Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids J. Endocrinol., March 1, 2008; 196(3): 455 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Mittermayer, G. Schaller, J. Pleiner, K. Krzyzanowska, S. Kapiotis, M. Roden, and M. Wolzt Rosiglitazone Prevents Free Fatty Acid-Induced Vascular Endothelial Dysfunction J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2574 - 2580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Daubert, M.-Y. Chung, and V. L. Brooks Insulin resistance and impaired baroreflex gain during pregnancy Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2188 - R2195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. McMahon, L. D. Ferreira, N. Ratnam, R. J. Davey, L. M. Youngs, E. A. Davis, P. A. Fournier, and T. W. Jones Glucose Requirements to Maintain Euglycemia after Moderate-Intensity Afternoon Exercise in Adolescents with Type 1 Diabetes Are Increased in a Biphasic Manner J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 963 - 968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Saks, R. Favier, R. Guzun, U. Schlattner, and T. Wallimann Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands J. Physiol., December 15, 2006; 577(3): 769 - 777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Haider, F. Mittermayer, G. Schaller, M. Artwohl, S. M. Baumgartner-Parzer, G. Prager, M. Roden, and M. Wolzt Free fatty acids normalize a rosiglitazone-induced visfatin release Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E885 - E890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Beha, H.-P. Juretschke, J. Kuhlmann, C. Neumann-Haefelin, U. Belz, M. Gerl, W. Kramer, M. Roden, and A. W. Herling Muscle type-specific fatty acid metabolism in insulin resistance: an integrated in vivo study in Zucker diabetic fatty rats Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E989 - E997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fediuc, M. P. Gaidhu, and R. B. Ceddia Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells J. Lipid Res., February 1, 2006; 47(2): 412 - 420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Brehm, M. Krssak, A. I. Schmid, P. Nowotny, W. Waldhausl, and M. Roden Increased Lipid Availability Impairs Insulin-Stimulated ATP Synthesis in Human Skeletal Muscle Diabetes, January 1, 2006; 55(1): 136 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Tremblay, M. Krebs, L. Dombrowski, A. Brehm, E. Bernroider, E. Roth, P. Nowotny, W. Waldhausl, A. Marette, and M. Roden Overactivation of S6 Kinase 1 as a Cause of Human Insulin Resistance During Increased Amino Acid Availability Diabetes, September 1, 2005; 54(9): 2674 - 2684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Pehleman, S. J. Peters, G. J. F. Heigenhauser, and L. L. Spriet Enzymatic regulation of glucose disposal in human skeletal muscle after a high-fat, low-carbohydrate diet J Appl Physiol, January 1, 2005; 98(1): 100 - 107. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
