| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
REVIEW
Departments of Internal Medicine and Cellular and Molecular Physiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 gerald.
shulman{at}yale.edu
Insulin resistance plays a major role in the pathogenesis of type 2 diabetes, yet despite much research the underlying mechanism responsible for it is poorly understood. In this review, some recent advances in the understanding of insulin resistance in humans that have been made by using magnetic resonance spectroscopy are discussed.
* In contrast to humans, A-ZIP/F fatless mice have significant expression of PPAR-
in liver.
This article has been cited by other articles:
|
|
 |
|
  N. Moller and J. O. L. Jorgensen Effects of Growth Hormone on Glucose, Lipid, and Protein Metabolism in Human Subjects Endocr. Rev., April 1, 2009; 30(2): 152 - 177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. Gormsen, B. Nellemann, L. P. Sorensen, M. D. Jensen, J. S. Christiansen, and S. Nielsen Impact of body composition on very-low-density lipoprotein-triglycerides kinetics Am J Physiol Endocrinol Metab, January 1, 2009; 296(1): E165 - E173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Nielsen, L. C. Gormsen, N. Jessen, S. B. Pedersen, N. Moller, S. Lund, and J. O. L. Jorgensen Growth Hormone Signaling in Vivo in Human Muscle and Adipose Tissue: Impact of Insulin, Substrate Background, and Growth Hormone Receptor Blockade J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2842 - 2850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Doenst, H. Bugger, M. Schwarzer, G. Faerber, M. A. Borger, and F. W. Mohr Three good reasons for heart surgeons to understand cardiac metabolism Eur. J. Cardiothorac. Surg., May 1, 2008; 33(5): 862 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Chen, B. Brar, C. S. Choi, D. Rousso, J. Vaughan, Y. Kuperman, S. N. Kim, C. Donaldson, S. M. Smith, P. Jamieson, et al. Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle PNAS, October 31, 2006; 103(44): 16580 - 16585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Carey, G. R. Steinberg, S. L. Macaulay, W. G. Thomas, A. G. Holmes, G. Ramm, O. Prelovsek, C. Hohnen-Behrens, M. J. Watt, D. E. James, et al. Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase. Diabetes, October 1, 2006; 55(10): 2688 - 2697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. A Carpentier, L. Portois, and W. J Malaisse n-3 Fatty acids and the metabolic syndrome Am. J. Clinical Nutrition, June 1, 2006; 83(6): S1499 - 1504S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. McGavock, R. G. Victor, R. H. Unger, and L. S. Szczepaniak Adiposity of the Heart*, Revisited Ann Intern Med, April 4, 2006; 144(7): 517 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. D'Eon, S. C. Souza, M. Aronovitz, M. S. Obin, S. K. Fried, and A. S. Greenberg Estrogen Regulation of Adiposity and Fuel Partitioning: EVIDENCE OF GENOMIC AND NON-GENOMIC REGULATION OF LIPOGENIC AND OXIDATIVE PATHWAYS J. Biol. Chem., October 28, 2005; 280(43): 35983 - 35991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Razak and S. S Anand Vascular viewpoint Vascular Medicine, August 1, 2004; 9(3): 223 - 224. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
