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Physiology 19: 183-190, 2004; doi:10.1152/physiol.00007.2004
1548-9213/04 $5.00
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Physiology, Vol. 19, No. 4, 183-190, August 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Unraveling the Cellular Mechanism of Insulin Resistance in Humans: New Insights from Magnetic Resonance Spectroscopy

Gerald I. Shulman

Departments of Internal Medicine and Cellular and Molecular Physiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 gerald.
shulman{at}yale.edu

Insulin resistance plays a major role in the pathogenesis of type 2 diabetes, yet despite much research the underlying mechanism responsible for it is poorly understood. In this review, some recent advances in the understanding of insulin resistance in humans that have been made by using magnetic resonance spectroscopy are discussed.

* In contrast to humans, A-ZIP/F fatless mice have significant expression of PPAR-{gamma} in liver.




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