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Physiology 19: 198-206, 2004; doi:10.1152/physiol.00006.2004
1548-9213/04 $5.00
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Physiology, Vol. 19, No. 4, 198-206, August 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Why Trypanosomes Cause Sleeping Sickness

Gabriella B. Lundkvist

Department of Biology, University of Virginia Charlottesville, Virginia 22904

Krister Kristensson

Department of Neuroscience, Karolinska Institutet, Stockholm, SE-171 77 Sweden

Marina Bentivoglio

Department of Neuroscience, Karolinska Institutet, Stockholm, SE-171 77 Sweden
krister.kristensson{at}neuro.ki.se

African trypanosomiasis or sleeping sickness is hallmarked by sleep and wakefulness disturbances. In contrast to other infections, there is no hypersomnia, but the sleep pattern is fragmented. This overview discusses that the causative agents, the parasites Trypanosoma brucei, target circumventricular organs in the brain, causing inflammatory responses in hypothalamic structures that may lead to dysfunctions in the circadian-timing and sleep-regulatory systems.






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