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Physiology 19: 207-215, 2004; doi:10.1152/physiol.00005.2004
1548-9213/04 $5.00
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Physiology, Vol. 19, No. 4, 207-215, August 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

The pH of the Secretory Pathway: Measurement, Determinants, and Regulation

Paul Paroutis, Nicolas Touret and Sergio Grinstein

Cell Biology Program, Hospital for Sick Children, Toronto M5G 1X8, and Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada
sga{at}sickkids.ca

The luminal pH of the secretory pathway plays a critical role in the posttranslational modification and sorting of proteins and lipids. The pH of each one of the organelles that constitute the pathway is unique, becoming more acidic as the biosynthetic cargo approaches its destination. The methods used for measurement of pH in the secretory pathway, its determinants, and its regulation are the subjects of this review.




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