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Physiology 19: 240-244, 2004; doi:10.1152/physiol.00015.2004
1548-9213/04 $5.00
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Physiology, Vol. 19, No. 5, 240-244, October 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

EMERGING TOPICS

First Encounter: How Pathogens Compromise Epithelial Transport

Karl Kunzelmann

Institut für Physiologie, Universität Regensburg, D-93053 Regensburg, Germany

Brendan McMorran

Institute of Molecular Bioscience, The University of Queensland, St. Lucia, 4072 Queensland, Australia

uqkkunze{at}mailbox.uq.edu.au

Pathogenic organisms trigger numerous signaling pathways that ultimately lead to drastic changes in physiological functions. Apart from altering structure and function of the epithelial tight junction barrier and activating inflammatory cascades, they induce changes in fluid and electrolyte transport. Pathogens do so by activating or by inhibiting ion channels and transporters, and the result might be to their benefit or to their disadvantage.




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