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Physiology 19: 245-252, 2004; doi:10.1152/physiol.00009.2004
1548-9213/04 $5.00
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Physiology, Vol. 19, No. 5, 245-252, October 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Deciphering the Renal Code: Advances in Conditional Gene Targeting

Alexander Gawlik1,2 and Susan E. Quaggin1,3

1 Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto M5G 1X5;
2 Deptartment of Medicine II, University Hospital Aachen, 52070 Aachen, Germany; and
3 Division of Nephrology, Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto M5B 1W8, Canada

quaggin{at}mshri.on.ca

Several powerful new techniques can examine gene function in mammals. Recombinase systems and kidney-specific promoters enable gene knockout and overexpression. Genetic systems induced on administration or removal of antibiotics or hormones permit control of gene expression. Gene silencing using short interfering RNA expression systems should accelerate loss-of-function studies. Thorough characterization of animals that have undergone conditional gene targeting has already provided insights into renal development and diseases. Here we discuss the advantages and pitfalls of currently available gene-targeting systems.






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Copyright © 2004 by the Int. Union Physiol. Sci./Am. Physiol. Soc.