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Physiology 19: 253-261, 2004; doi:10.1152/physiol.00012.2004
1548-9213/04 $5.00
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Physiology, Vol. 19, No. 5, 253-261, October 2004
© 2004 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

A Hypothesis About the Role of Adult Neurogenesis in Hippocampal Function

Alejandro F. Schinder

Laboratory of Neuronal Plasticity, Leloir Institute Foundation, 1405 Buenos Aires, Argentina

Fred H. Gage

Laboratory of Genetics, The Salk Institute, La Jolla, California 92037

aschinder{at}leloir.org.ar

The functional relevance of adult hippocampal neurogenesis has long been a matter of intense experimentation and debate, but the precise role of new neurons has not been sufficiently elaborated. Here we propose a hypothesis in which specific features of newly generated neurons contribute to hippocampal plasticity and function and discuss the most recent and relevant findings in the context of the proposed hypothesis.




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